![]() Neuron cell bodies in Aplysia range from 30 µm to over 250 µm. We tested CFEs for intracellular stimulation using the large identified and electrically compact neurons of the marine mollusk Aplysia californica. The small fiber size suggests that arrays could be used for intracellular stimulation. They have good signal-to-noise ratios (SNRs) and provide stable extracellular recordings both acutely and chronically in neural tissue in vivo (e.g. Carbon fiber electrodes (CFEs) are 8 µm-diameter electrodes that can be assembled into dense arrays (pitches ⩾ 80 µm). ![]() More recently, devices with high electrode density have been developed, but few of them can be used for intracellular recording or stimulation in intact nervous systems. Traditional recording methods, such as glass microelectrodes, can only control a small number of neurons. To understand neural circuit dynamics, it is critical to manipulate and record many individual neurons. Robotics Program, University of Michigan, Ann Arbor, MI, United States of Americaĭepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, United States of Americaĭepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States of America Neurosciences Program, University of Michigan, Ann Arbor, MI, United States of America Department of Biology, Case Western Reserve University, Cleveland, OH, United States of Americaĭepartment of Neurosciences, University of Rochester, Rochester, NY, United States of Americaĭepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States of Americaīiointerfaces Institute, University of Michigan, Ann Arbor, MI, United States of Americaĭepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, United States of Americaĭepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, United States of America
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